International Journal of Contemporary Research in Multidisciplinary

Abstract:

The role of metal ions in enzyme catalysis and human health is a critical subject that integrates biochemistry, clinical medicine, and nutrition, highlighting their main form of indispensable functions in sustaining physiological and metabolic processes. Metal ions such as zinc, magnesium, iron, copper, as well as manganese serve as the main essential cofactors for the purpose of numerous enzymes, playing pivotal roles in stabilizing protein structures, facilitating catalytic reactions, and regulating metabolic pathways. Their involvement in crucial biochemical processes, together with oxidative phosphorylation, DNA synthesis, neurotransmission, and antioxidant protection, underscores their significance in maintaining cell function and normal fitness. The biochemical residences of these steel ions, especially their ability to mediate electron transfer, stabilize transition states, and participate in redox reactions, lead them to critical in enzymatic function. However, disruptions in metallic ion homeostasis—whether or not due to deficiency, toxicity, or impaired absorption—are linked to a huge variety of medical conditions, together with anemia, neurodegenerative sicknesses, immune dysfunction, metabolic syndromes, and cardiovascular issues. Clinical studies have established the excessive physiological outcomes of those imbalances, necessitating nutritional regulation, supplementation techniques, and recovery interventions. The function of metal-based prescribed drugs, which incorporates platinum-based chemotherapeutics like cisplatin, highlights their capacity for targeted therapies, even though their toxicity risks require cautious control. The dietary aspect further emphasizes the need for ok dietary consumption of essential minerals, as deficiencies due to a poor diet or inhibitory compounds in plant-based definitely foods can cause massive health issues. Advances in studies methodologies, consisting of molecular modeling, excessive-decision imaging, and genetic screening, gift opportunities for precision medicine, bearing in mind targeted restoration strategies to optimize metallic ion balance. Future research must interest on refining drug shipping systems, evaluating the lengthy-term effects of supplementation and chelation cures, and carrying out massive-scale studies to assess the impact of nutritional interventions on public health. Additionally, public health policies must consist of findings from biochemical and scientific studies to sell attention, preventive measures, and effective remedy techniques for metallic ion-associated troubles.

Keywords:

Metal Ions, Enzyme Catalysis, Human Health, Biochemical Processes, Metalloenzymes

Aim/Objectives

Methods